Hydrochloric Acid → 2-Amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol

HRID 1892047노트

반응식

HRID 1892047 반응식
[CH3:1][C:2]1([CH2:12][O:13]CC#C)[NH:6][C:5]2(CCC[CH2:8][CH2:7]2)[O:4][CH2:3]1.Cl>O>[NH2:6][C:2]([CH3:1])([CH2:3][O:4][CH2:5][C:7]#[CH:8])[CH2:12][OH:13]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 595654083-Methyl-3-prop-2-ynyloxymethyl-1-oxa-4-aza-spiro[4.5]decane

생성물 1

HCID 595653842-Amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol수율 102.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

3-Methyl-3prop-2-ynyloxymethyl-1-oxa-4-aza-spiro[4.5]decane (1.83 g) in an aqueous solution of HCl (6N) (2.73 ml) were refluxed for 1 hr. The reaction mixture was cooled down to room temperature, diluted with water and extracted thrice with ethyl ether. The two layers were separated. The aqueous layer was concentrated under reduced pressure and further co-evaporated with toluene to yield 2-amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol hydrochloric salt (1.205 g) as a white beige solid which was used in the next step without any further purification.

후처리

  1. extractionextracted thrice with ethyl ether
  2. customThe two layers were separated
  3. concentrationThe aqueous layer was concentrated under reduced pressure and further co-evaporated with toluene

출처 및 근거

ORD 기록
ord-4a2ffbaad6f44822a495c36fe6bd05f5
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507509B2

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