Phosphorus oxychloride → HCID 269162, 화합물

HRID 1892278노트

반응식

HRID 1892278 반응식
[CH3:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:13])[CH:8]=[CH:9][C:10]=2[CH3:12])[N:5]=[C:4](O)[CH:3]=1.O=P(Cl)(Cl)[Cl:17]>C1(C)C=CC=CC=1>[Cl:17][C:4]1[CH:3]=[C:2]([CH3:1])[C:11]2[C:6](=[C:7]([CH3:13])[CH:8]=[CH:9][C:10]=2[CH3:12])[N:5]=1

참가 물질

4

반응물 2

HCID 24813Phosphorus oxychlorideHCID 178424527HCID 178424527, 화합물

생성물 1

HCID 269162HCID 269162, 화합물수율 85%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 4,5,8-trimethylquinolin-2-ol (2.40 g, 12.8 mmol) and 1.4 mL (1.2 eq) of POCl3 in toluene was reacted as outlined in Scheme 1 above to yield the desired title compound (2.2 g, 85%). Spectroscopic data: 1H NMR (300 MHz, CDCl3) δ ppm 2.68 (s, 3 H) 2.82 (s, 3 H) 2.85 (s, 3 H) 7.12 (s, 1 H) 7.18 (d, J=7.33 Hz, 1 H) 7.39 (d, 1 H).

출처 및 근거

ORD 기록
ord-7d9c4167135243659dea219370869513
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507682B2

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