[C:1]([N:8]1[CH:12]=[CH:11]N=C1)([N:3]1C=CN=C1)=[O:2].[C:13]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])(=[O:16])[NH:14]N.NCC[C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=1.O>O1CCCC1>[OH:31][C:28]1[CH:29]=[CH:30][C:25]([CH2:11][CH2:12][NH:8][C:1]([NH:3][NH:14][C:13]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])=[O:2])=[CH:26][CH:27]=1To a suspension of 1,1′-carbonyldiimidazole (1.621 g, 9.994 mmol) in anhydrous tetrahydrofuran (20 ml) was added tert-butyl carbazate (1.322 g, 10.00 mmol), and the mixture was stirred at room temperature for 1.5 hr. 4-(2-Aminoethyl)phenol (1.371 g, 9.991 mmol) was added and the mixture was stirred at room temperature for 6 hr. Water (40 ml) was added to the reaction mixture and the precipitate was collected by filtration, washed 3 times with water and twice with ethyl acetate, and dried under reduced pressure to give tert-butyl 2-{[2-(4-hydroxyphenyl)ethyl]carbamoyl}hydrazinecarboxylate (2.417 g, 8.184 mmol, yield 81.9%) as a white solid.
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