Hydrochloric Acid → 5-tert-butyl-2-nitro-1H-pyrrole-3-carboxylic acid

HRID 18935노트

반응식

HRID 18935 반응식
[C:1]([C:5]1[NH:9][C:8]([N+:10]([O-:12])=[O:11])=[C:7]([C:13]([O:15]C)=[O:14])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[K+].Cl>>[C:1]([C:5]1[NH:9][C:8]([N+:10]([O-:12])=[O:11])=[C:7]([C:13]([OH:15])=[O:14])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 59345806methyl 5-tert-butyl-2-nitro-1H-pyrrole-3-carboxylate

생성물 1

HCID 586792985-tert-butyl-2-nitro-1H-pyrrole-3-carboxylic acid수율 89%

반응 조건

온도
80 °C

실험 절차

To methyl 5-tert-butyl-2-nitro-1H-pyrrole-3-carboxylate (900 mg, 3.98 mmol) was added 12% aqueous KOH (5 mL), and the resulting reaction mixture was stirred at 80° C. for 30 min. The reaction mixture was poured into 1N aqueous HCl (excess), the aqueous phase was extracted 3 times with dichloromethane, the combined organic layers was dried and concentrated under vacuum to afford 5-tert-butyl-2-nitro-1H-pyrrole-3-carboxylic acid (5) as yellow solid (750 mg, 89%).

후처리

  1. customthe resulting reaction mixture
  2. extractionthe aqueous phase was extracted 3 times with dichloromethane
  3. customthe combined organic layers was dried
  4. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-7ecb447ff65f4a72941e0cbdcdcc8e86
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741479B2

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