Thiourea → HCID 86665174, 화합물

HRID 1893721노트

반응식

HRID 1893721 반응식
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13](=O)[CH2:14]Br)[CH:10]=[N:9]2)=[CH:5][CH:4]=1.[NH2:19][C:20]([NH2:22])=[S:21]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13]3[N:19]=[C:20]([NH2:22])[S:21][CH:14]=3)[CH:10]=[N:9]2)=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 2723790ThioureaHCID 866423312-Bromo-1-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)ethanone

생성물 1

HCID 86665174HCID 86665174, 화합물수율 83.9%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

According to Scheme 6, Step 1: A solution of 1-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-bromoethanone (9.70 mmol, 3.00 g) and of thiourea (9.70 mmol, 739 mg) in acetone (20 mL) was stirred under reflux for 1 hour. After filtration and evaporation of the filtrate, the white solid was partitioned between EtOAc and a saturated solution of Na2CO3. The aqueous phase was extracted with EtOAc. The organic phase was dried over Na2SO4, was filtered and was concentrated to yield 4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-amine (8.14 mmol, 2.33 g) as an orange foam.

후처리

  1. temperatureunder reflux for 1 hour
  2. filtrationAfter filtration and evaporation of the filtrate
  3. customthe white solid was partitioned between EtOAc
  4. extractionThe aqueous phase was extracted with EtOAc
  5. dry with materialThe organic phase was dried over Na2SO4
  6. filtrationwas filtered
  7. concentrationwas concentrated

출처 및 근거

ORD 기록
ord-72713a5767034d60b0ee9f0e8901310c
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513252B2

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