Iodoethane → HCID 67205011, 화합물

HRID 1894318노트

반응식

HRID 1894318 반응식
[CH2:1]([O:3][C:4](=[O:16])[C:5]1[C:10]([OH:11])=[CH:9][C:8]([C:12]([CH3:15])([CH3:14])[CH3:13])=[N:7][CH:6]=1)[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:23](I)[CH3:24]>CN(C)C=O.O.[Cl-].[Na+].O>[CH2:1]([O:3][C:4](=[O:16])[C:5]1[C:10]([O:11][CH2:23][CH3:24])=[CH:9][C:8]([C:12]([CH3:15])([CH3:14])[CH3:13])=[N:7][CH:6]=1)[CH3:2]

참가 물질

7

반응물 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 178469765HCID 178469765, 화합물

생성물 1

HCID 67205011HCID 67205011, 화합물수율 80%

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 57417360Sodium chloride; water용매

실험 절차

6-tert-Butyl-4-hydroxy-nicotinic acid ethyl ester (110 mg, 0.5 mmol) was dissolved in dimethylformamide (6 mL). Potassium carbonate was added followed by dropwise addition of ethyl iodine (0.13 mL, 1.5 mmol). The reaction mixture was stirred at room temperature overnight. It was diluted with water and brine and extracted with diethyl ether (2×30 mL). Combined organics washed with brine/water, dried and concentrated to give 6-tert-butyl-4-ethoxy-nicotinic acid ethyl ester as viscous oil (100 mg, 80%). LR-MS: 251 [(M+H)+]

후처리

  1. extractionextracted with diethyl ether (2×30 mL)
  2. washCombined organics washed with brine/water
  3. customdried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2607a40e64bd4ba6b10ccc5724155844
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513239B2

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