Hydrochloric Acid → Methyl 6-aminoquinoline-3-carboxylate dihydrochloride

HRID 1894957노트

반응식

HRID 1894957 반응식
C(OC([NH:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]=[CH:14][C:13]([C:19]([O:21][CH3:22])=[O:20])=[CH:12]2)=O)(C)(C)C.[ClH:23].O1CCOCC1>C(Cl)Cl>[ClH:23].[ClH:23].[NH2:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]=[CH:14][C:13]([C:19]([O:21][CH3:22])=[O:20])=[CH:12]2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67002181Methyl 6-(tert-butoxycarbonylamino)quinoline-3-carboxylate

생성물 1

HCID 67002244Methyl 6-aminoquinoline-3-carboxylate dihydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of methyl 6-[(tert-butoxycarbonyl)amino]quinoline-3-carboxylate (Int-2, 1.28 g, 4.23 mmol) in methylene chloride (38 mL) was added hydrochloric acid in 1,4-dioxane (4.0 M, 10.6 mL, 42.3 mmol). The reaction was stirred at room temperature overnight then concentrated under reduced pressure. The crude reside was dried in vacuo and used as obtained. LC-MS: (FA) ES+ 203; 1H NMR (400 MHz, d6-DMSO) δ ppm 9.14 (s, 1H), 9.08 (d, J=1.8 Hz, 1H), 8.10 (d, J=9.1 Hz, 1H), 7.62 (dd, J=9.1, 2.4 Hz, 1H), 7.33 (d, J=1.7 Hz, 1H), 3.96 (s, 9H).

후처리

  1. concentrationthen concentrated under reduced pressure
  2. customThe crude reside was dried in vacuo
  3. customas obtained

출처 및 근거

ORD 기록
ord-1d17512a48954b0083454f4a875fba2c
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513421B2

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