Tetrahydrofuran → 2-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid

HRID 1895389노트

반응식

HRID 1895389 반응식
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[S:9][CH:10]=1)=[O:5])C.O1CCCC1.[OH-].[Na+]>CO>[N:15]1[CH:16]=[CH:17][C:12]([NH:11][C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)=[CH:13][CH:14]=1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 27420752-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid ethyl ester

생성물 1

HCID 181867402-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid (160 mg) was prepared according to General Procedure C using 2-(pyridin-4-ylamino)-thiazole-4-carboxylic acid ethyl ester in methanol:tetrahydrofuran:2N NaOH (1:1:1, 1.5 mL). The solvents were evaporated and the compound was dried. The crude product was used without further purification.

후처리

  1. customThe solvents were evaporated
  2. customthe compound was dried
  3. customThe crude product was used without further purification

출처 및 근거

ORD 기록
ord-8a86c1ceea4c4d9b870e0da0a508ccf4
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513430B2

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