Tetrahydrofuran → 2-(3-Pyridinylamino)-4-thiazolecarboxylic acid

HRID 1895391노트

반응식

HRID 1895391 반응식
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[S:9][CH:10]=1)=[O:5])C.O1CCCC1.[OH-].[Na+]>CO>[N:14]1[CH:15]=[CH:16][CH:17]=[C:12]([NH:11][C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH:13]=1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 52903990HCID 52903990, 화합물

생성물 1

HCID 529035842-(3-Pyridinylamino)-4-thiazolecarboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid (165 mg) was prepared according to General Procedure C using 2-(pyridin-3-ylamino)-thiazole-4-carboxylic acid ethyl ester in methanol:tetrahydrofuran:2N NaOH (1:1:1, 1.5 mL). The solvents were evaporated and the compound was dried. The crude product was used without further purification.

후처리

  1. customThe solvents were evaporated
  2. customthe compound was dried
  3. customThe crude product was used without further purification

출처 및 근거

ORD 기록
ord-95270e6983294e26ab93f029557e5b78
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08513430B2

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