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Hydrochloric Acid → 1-(4-Bromo-1-naphthalenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-buten-1-one

HRID 1895405
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HRID 1895405 반응식
S(Cl)(Cl)=O.[Br:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([C:16](=[O:32])[CH2:17][C:18]([C:24]2[CH:29]=[C:28]([Cl:30])[CH:27]=[C:26]([Cl:31])[CH:25]=2)(O)[C:19]([F:22])([F:21])[F:20])=[CH:8][CH:7]=1.Cl>C1(C)C=CC=CC=1>[Br:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([C:16](=[O:32])[CH:17]=[C:18]([C:24]2[CH:25]=[C:26]([Cl:31])[CH:27]=[C:28]([Cl:30])[CH:29]=2)[C:19]([F:21])([F:22])[F:20])=[CH:8][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 866732401-(4-Bromo-1-naphthalenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxy-1-butanone

생성물 1

HCID 866461861-(4-Bromo-1-naphthalenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-buten-1-one수율 95%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

A solution of thionyl chloride (0.5 g, 4.46 mmol) in toluene (2 mL) was added dropwise to the product of Step A (1.1 g, 2.23 mmol) in toluene (10 mL) at 65° C. The mixture was cooled to ambient temperature and then poured into 1N hydrochloric acid (50 mL). The resulting mixture was extracted with ethyl acetate (2×25 mL). The combined extracts were dried and evaporated to give the title product as an oil (1.0 g, 95% yield).

후처리

  1. extractionThe resulting mixture was extracted with ethyl acetate (2×25 mL)
  2. customThe combined extracts were dried
  3. customevaporated

출처 및 근거

ORD 기록
ord-844f836a15c14fafad41a336755bb7e9
출처 데이터셋
uspto-grants-2013_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08513431B2

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