Hydrochloric Acid → HCID 16788087, 화합물

HRID 1896015노트

반응식

HRID 1896015 반응식
[OH-].[K+].[N+:3]([C:6]1[C:7]([N:12]2[CH2:17][CH2:16][CH:15]([C:18]([O:20]CC)=[O:19])[CH2:14][CH2:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1)([O-:5])=[O:4].Cl>CO.O>[N+:3]([C:6]1[C:7]([N:12]2[CH2:17][CH2:16][CH:15]([C:18]([OH:20])=[O:19])[CH2:14][CH2:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1)([O-:5])=[O:4]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 60631682HCID 60631682, 화합물

생성물 1

HCID 16788087HCID 16788087, 화합물수율 134.6%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

To a solution of KOH (0.46 g, 8.16 mmol) in methanol (30 mL) and water (30 mL) was added Compound 258a (1.14 g, 4.08 mmol). The solution was stirred at r.t. for 1.5 hours, poured into water, acidified with 2M HCl and extracted with EtOAc. The combined organic layers were washed with brine, dried on Na2SO4 and evaporated to dryness in vacuo to afford the title product (1.38 g).

후처리

  1. extractionextracted with EtOAc
  2. washThe combined organic layers were washed with brine
  3. customdried on Na2SO4
  4. customevaporated to dryness in vacuo

출처 및 근거

ORD 기록
ord-3a325d3a9a864dac870a7fcc5190a601
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518916B2

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