Adenine → 9-(3-chloropropyl)-9H-purin-6-amine

HRID 1896072

반응식

HRID 1896072 반응식
[N:1]1[C:9]([NH2:10])=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.Br[CH2:12][CH2:13][CH2:14][Cl:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:15][CH2:14][CH2:13][CH2:12][N:5]1[CH:6]=[N:7][C:8]2[C:4]1=[N:3][CH:2]=[N:1][C:9]=2[NH2:10]

참가 물질

5

반응물 3

HCID 190AdenineHCID 80061-Bromo-3-chloropropaneHCID 11430Potassium Carbonate

생성물 1

HCID 2865919-(3-chloropropyl)-9H-purin-6-amine수율 59%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of adenine (4.05 g, 30 mM), 1-bromo-3-chloropropane (21.3 g, 13.4 mM), and potassium carbonate (10.4 g, 75 mM) in DMF (200 mL) was stirred at room temperature under argon for 4 days, filtrated, and evaporated to dryness. The crude product was washed with water and dried. Recrystallization from ethanol gave 9-(3-chloropropyl)adenine in 59% yield.

후처리

  1. filtrationfiltrated
  2. customevaporated to dryness
  3. washThe crude product was washed with water
  4. customdried
  5. customRecrystallization from ethanol

출처 및 근거

ORD 기록
ord-e475fa1b02de4f09940ae50d54b7dd4a
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518885B2

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