1-(2-ethoxyethyl)-3-ethyl-4-nitro-1H-pyrazole-5-carboxamide → 4-amino-1-(2-ethoxyethyl)-3-ethyl-1H-pyrazole-5-carboxamide

HRID 1896198

반응식

HRID 1896198 반응식
[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[C:10]([C:11]([NH2:13])=[O:12])=[C:9]([N+:14]([O-])=O)[C:8]([CH2:17][CH3:18])=[N:7]1)[CH3:2].[H][H]>[Pt].C(OC(C)C)(=O)C>[NH2:14][C:9]1[C:8]([CH2:17][CH3:18])=[N:7][N:6]([CH2:5][CH2:4][O:3][CH2:1][CH3:2])[C:10]=1[C:11]([NH2:13])=[O:12]

참가 물질

5

반응물 2

HCID 577445561-(2-ethoxyethyl)-3-ethyl-4-nitro-1H-pyrazole-5-carboxamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 577445394-amino-1-(2-ethoxyethyl)-3-ethyl-1H-pyrazole-5-carboxamide

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 7915Isopropyl Acetate용매

실험 절차

1-(2-ethoxyethyl)-3-ethyl-4-nitro-1H-pyrazole-5-carboxamide from step 1 (15.0 g, 58 mmol), 5% Platinum-on-carbon (0.75 g), and isopropyl acetate (150 mL) were combined and the mixture was stirred under 80 psi of hydrogen for about 50 hours. The mixture was then filtered through celite, the celite was rinsed with acetonitrile, and the filtrate was concentrated. The material eventually crystallized to give 13.7 g as a hydrate of the title compound.

후처리

  1. filtrationThe mixture was then filtered through celite
  2. washthe celite was rinsed with acetonitrile
  3. concentrationthe filtrate was concentrated
  4. customThe material eventually crystallized

출처 및 근거

ORD 기록
ord-fe48cc5037154e5db3225d1bb8c24ee2
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518956B2

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