Water → 6-chloro-3-(6-chloropyrazin-2-yl)-3H-imidazo[4,5-c]pyridine 6-chloro-1-(6-chloropyrazin-2-yl)-1H-imidazo[4,5-c]pyridine

HRID 1896207노트

반응식

HRID 1896207 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]2[NH:8][CH:9]=[N:10][C:4]=2[CH:3]=1.[Cl:11][C:12]1[CH:17]=[N:16][CH:15]=[C:14]([Cl:18])[N:13]=1.[F-].[Cs+].O>CS(C)=O>[Cl:1][C:2]1[N:7]=[CH:6][C:5]2[N:8]([C:14]3[CH:15]=[N:16][CH:17]=[C:12]([Cl:11])[N:13]=3)[CH:9]=[N:10][C:4]=2[CH:3]=1.[Cl:1][C:2]1[N:7]=[CH:6][C:5]2[N:8]=[CH:9][N:10]([C:12]3[CH:17]=[N:16][CH:15]=[C:14]([Cl:18])[N:13]=3)[C:4]=2[CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 25953Cesium fluorideHCID 785042,6-DichloropyrazineHCID 218138956-Chloro-3H-imidazo(4,5-c)pyridine

생성물 1

HCID 866543176-chloro-3-(6-chloropyrazin-2-yl)-3H-imidazo[4,5-c]pyridine 6-chloro-1-(6-chloropyrazin-2-yl)-1H-imidazo[4,5-c]pyridine

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

A mixture of 6-chloro-3H-imidazo[4,5-c]pyridine (4.6 g, 30 mmol), 2,6-dichloropyrazine (6 g, 40.5 mmol) and CsF (9.1 g, 60 mmol) in dry DMSO (80 mL) was stirred at room temperature for 20 h under N2. The mixture was poured into water (50 mL) with stirring. The formed precipitate was collected by filtration. The filter cake was suspended in MeOH (20 mL) and filtered again. The filter cake was collected and dried in vacuum which gave a mixture of title compounds 18a & 17a as a white solid (5.0 g, 62.9%).

후처리

  1. stirringwith stirring
  2. filtrationThe formed precipitate was collected by filtration
  3. filtrationfiltered again
  4. customThe filter cake was collected
  5. customdried in vacuum which
  6. customgave

출처 및 근거

ORD 기록
ord-46677eac6d294294a28584219bfc6d41
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518952B2

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