Ammonia → 2-(4-Methoxyphenyl)acetamide

HRID 1896240노트

반응식

HRID 1896240 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1.S(Cl)(Cl)=O.[NH3:17]>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([NH2:17])=[O:12])=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 76904-Methoxyphenylacetic AcidHCID 24386Thionyl Chloride

생성물 1

HCID 2418682-(4-Methoxyphenyl)acetamide수율 70%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 2-(4-methoxyphenyl)acetic acid (500 mg, 3.00 mmol) in DCM (30 ml) was added thionyl chloride (0.4 ml, 4.5 mmol) at 0° C. The reaction mixture was allowed to warm up to room temperature and continued to stirred overnight. Then aqueous ammonia (2 ml) was added to the reaction mixture. The white solid forming was filtered and dried under vacuum to obtained 350 mg (70%) of 2-(4-methoxyphenyl)acetamide as a white solid.

후처리

  1. customThe white solid forming
  2. filtrationwas filtered
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-5ad97b8f130c4fa1b36f0b06d47086ca
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518948B2

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