Lithium Hydroxide → 5-(2-Furyl)isoxazole-3-carboxylic acid
반응식
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[O:12][CH:13]=[CH:14][CH:15]=2)[O:8][N:7]=1)=[O:5])C.[OH-].[Li+]>C1COCC1.CO>[O:12]1[CH:13]=[CH:14][CH:15]=[C:11]1[C:9]1[O:8][N:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:10]=1참가 물질
5
실험 절차
To a solution of 5-furan-2-yl-isoxazole-3-carboxylic acid ethyl ester (4.14 g) in THF (130 mL) and methanol (25 mL) was slowly added 1N lithium hydroxide aqueous solution (80 mL). The resulting mixture was stirred for 15 hours, and then concentrated under reduced pressure. The remaining solution was acidified with 1N hydrochloric acid to form a solid, and the solid was filtered, washed with distilled water, dried to give 3.22 g of 5-furan-2-yl-isoxazole-3-carboxylic acid (yield: 90%) as a white solid.
후처리
- concentrationconcentrated under reduced pressure
- customto form a solid
- filtrationthe solid was filtered
- washwashed with distilled water
- customdried
출처 및 근거
- ORD 기록
- ord-5f015aed813540e08b758222af6fb3dd
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08518978B2
반응 노트
불러오는 중…