Hydrazine hydrate (1:1) → 2-(6-(2-Fluorophenyl)pyridin-3-yloxy)ethylamine

HRID 1896710노트

반응식

HRID 1896710 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][N:17]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:10][CH:9]=1.O.NN>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][NH2:17])=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 597613522-(2-(6-(2-Fluorophenyl)pyridin-3-yloxy)ethyl)isoindole-1,3-dione

생성물 1

HCID 691059192-(6-(2-Fluorophenyl)pyridin-3-yloxy)ethylamine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

189 mg (0.52 mmol) of (2-(2-(6-(2-fluorophenyl)pyridin-3-yloxy)ethyl)isoindole-1,3-dione and 236 mg (4.72 mmol) of hydrazine hydrate (24%) were stirred in 10 ml of ethanol under reflux for 7 h. After cooling the residue was filtered, washed and dried. Yield: 165 mg.

후처리

  1. temperatureunder reflux for 7 h
  2. temperatureAfter cooling the residue
  3. filtrationwas filtered
  4. washwashed
  5. customdried

출처 및 근거

ORD 기록
ord-b507f9d03dcb418792a315e246576b0c
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518976B2

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