Sodium Dithionite → 5-Amino-2-morpholin-4-yl-1,3-benzoxazole

HRID 1896763노트

반응식

HRID 1896763 반응식
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[O:8][C:9]3[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][C:10]=3[N:11]=2)[CH2:3][CH2:2]1.S(S([O-])=O)([O-])=O.[Na+].[Na+]>C(O)C.O.O>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[O:8][C:9]3[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][C:10]=3[N:11]=2)[CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 24489Sodium DithioniteHCID 127114612-Morpholino-5-nitrobenzo[d]oxazole

생성물 1

HCID 167689435-Amino-2-morpholin-4-yl-1,3-benzoxazole수율 30.7%

시약·촉매·용매 2

HCID 962Water용매HCID 19096565Water ethanol용매

실험 절차

A solution of 2-morpholino-5-nitrobenzo[d]oxazole (130 mg, 0.52 mmol) in ethanol/water 1:1 v/v (10 mL) was treated with sodium dithionite (182 mg, 1.04 mmol) at room temperature and then refluxed for 16 h. After cooling, the mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4 and evaporated to afford 35 mg (30%) of the title compound.

후처리

  1. temperaturerefluxed for 16 h
  2. temperatureAfter cooling
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic layer was dried over anhydrous MgSO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-4c407d27787a47e6a75b2e15a183ad34
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518980B2

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