Ethyl Acetate → HCID 45118147, 화합물

HRID 1896785노트

반응식

HRID 1896785 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH2:11])[CH:9]=2)[CH:4]=[CH:3]1.[C:12](Cl)(=[O:16])[CH:13]([CH3:15])[CH3:14].C(OCC)(=O)C>N1C=CC=CC=1>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][C:12](=[O:16])[CH:13]([CH3:15])[CH3:14])[CH:9]=2)[CH:4]=[CH:3]1

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 62325Isobutyryl chlorideHCID 105347991-methyl-1H-indol-6-amine

생성물 1

HCID 45118147HCID 45118147, 화합물수율 36.2%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 1-methyl-1H-indol-6-amine (45 mg, 0.31 mmol) in pyridine (2 mL) at room temperature was added isobutyryl chloride (35 μL, 0.34 mmol). The resulting mixture was stirred at room temperature for 16 h. Ethyl acetate was added and the organic layer was washed three times with brine. The combined organic layers were dried over anhydrous MgSO4 and evaporated to afford 24.3 mg (36%) of the title compound (LCMS RT=5.73 min, MH+ 217.2)

후처리

  1. washthe organic layer was washed three times with brine
  2. dry with materialThe combined organic layers were dried over anhydrous MgSO4
  3. customevaporated

출처 및 근거

ORD 기록
ord-3c408687a2b749529afbb1733d0bc22b
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518980B2

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