Thionyl Chloride → 6-Fluoro-2-naphthoyl chloride

HRID 1897577

반응식

HRID 1897577 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([OH:14])=O)[CH:6]=[CH:5]2.S(Cl)([Cl:17])=O>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([Cl:17])=[O:14])[CH:6]=[CH:5]2

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 27827886-Fluoro-2-naphthoic acid

생성물 1

HCID 866748346-Fluoro-2-naphthoyl chloride

실험 절차

6-fluoro-2-naphthoic acid (2 g, 10.52 mmol) was stirred in thionyl chloride (21.03 ml) at 80° C. for 4 h in pressure vessel. The mixture was cooled and concentrated. The acid chloride was dried and used as is for next step.

후처리

  1. temperatureThe mixture was cooled
  2. concentrationconcentrated
  3. dry with materialThe acid chloride was dried

출처 및 근거

ORD 기록
ord-9bce67345cf24d389ebf4192955b9154
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08519134B2

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