Isopropanol → 77092-47-8
반응식
[H-].[Na+].[CH:3]([OH:6])([CH3:5])[CH3:4].Br[CH2:8][CH:9]([O:13][CH2:14][CH3:15])[O:10][CH2:11][CH3:12]>C(Cl)Cl>[CH2:11]([O:10][CH:9]([O:13][CH2:14][CH3:15])[CH2:8][O:6][CH:3]([CH3:5])[CH3:4])[CH3:12]참가 물질
5
실험 절차
NaH (3.35 g, 84 mmol) was added to isopropanol (5.38 mL, 69.9 mmol) at 0° C. The reaction mixture was stirred at room temperature for 30 min followed by the addition of 2-bromo-1,1-diethoxyethane (7.89 mL, 52.4 mmol). The tube was sealed, heated to 120° C. and stirred overnight. The sealed tube was cooled to room temperature and the contents were dissolved in DCM and washed with water twice. The organic layer was separated, dried over sodium sulfate and concentrated in vacuo to give 2-(2,2-diethoxy-ethoxy)-propane, which was hydrolyzed according to the method described in example 29 to give crude isopropoxy-acetaldehyde.
후처리
- customThe tube was sealed
- temperatureheated to 120° C.
- stirringstirred overnight
- temperatureThe sealed tube was cooled to room temperature
- washwashed with water twice
- customThe organic layer was separated
- dry with materialdried over sodium sulfate
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-a4b473e1800146bcbd7c953911ff36d5
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08519134B2
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