Benzenesulfonyl chloride → HCID 18617378, 화합물

반응식

[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]([F:10])([F:9])[F:8])[C:3]=1[CH2:11][CH3:12].[C:13]1([S:19](Cl)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:11]([C:3]1[C:4]([C:7]([F:10])([F:9])[F:8])=[N:5][O:6][C:2]=1[NH:1][S:19]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:21])=[O:20])[CH3:12]

참가 물질

반응물 2

HCID 7369Benzenesulfonyl chloride

HCID 233729304-ethyl-3-(trifluoromethyl)-1,2-oxazol-5-amine

생성물 1

HCID 18617378HCID 18617378, 화합물수율 72%

실험 절차

N-(4-Ethyl-3-trifluoromethyl-5-isoxazolyl)benzenesulfonamide was prepared in the same manner as described in Example 42 from 5-amino-4-ethyl-3-trifluoromethylisoxazole and benzenesulfonyl chloride in 72% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give white needles, m.p. 105°-106.5° C.

후처리

customPurification
customwas achieved by recrystallization from ethyl acetate/hexanes
customto give white needles, m.p. 105°-106.5° C.

출처 및 근거

ORD 기록: ord-b1ed949aa75346fbb4b771980c726dcf
출처 데이터셋: uspto-grants-1996_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05571821

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