Propanedioic acid, 2-[2-(2-pyridinyl)ethyl]-, 1,3-diethyl ester → 4-(Pyridin-2-yl)butanoic acid

HRID 1900590노트

반응식

HRID 1900590 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][CH:9](C(OCC)=O)[C:10]([O:12]CC)=[O:11]>C(O)C.[OH-].[Na+]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11]

참가 물질

4

반응물 1

HCID 15591894Propanedioic acid, 2-[2-(2-pyridinyl)ethyl]-, 1,3-diethyl ester

생성물 1

HCID 137371714-(Pyridin-2-yl)butanoic acid수율 77.3%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A solution of diethyl β-(2-pyridyl)-ethylmalonate (25 g, 94 mmol) in ethanol (100 mL) and NaOH (1M, 200 mL) was refluxed for 2 hours. The ethanol was removed by distillation, and the solution was acidified with concentrated H2SO4. The resulting solution was refluxed for 30 minutes, and then the pH was adjusted to 4. The solvent was removed and the residue was dried under vacuum. The residue was suspended in ethanol and filtered. The ethanol was removed to yield 4-(2-pyridyl)butanoic acid (46) (12 g).

후처리

  1. customThe ethanol was removed by distillation
  2. temperatureThe resulting solution was refluxed for 30 minutes
  3. customThe solvent was removed
  4. customthe residue was dried under vacuum
  5. filtrationfiltered
  6. customThe ethanol was removed

출처 및 근거

ORD 기록
ord-00a521fd10b549be8faf3bd3be081d8e
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05576315

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