Ethanol → 1-(6-Chloro-4-(3,4-methylenedioxybenzyl)aminoquinazolin-2-yl)piperidine-4-carboxylic acid

HRID 1900691

반응식

HRID 1900691 반응식
[CH2:1]([OH:3])[CH3:2].[OH-:4].[Na+].C(OC1[CH2:14][CH2:13][N:12]([C:15]2[N:24]=[C:23]([NH:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]4[O:33][CH2:34][O:35][C:29]=4[CH:28]=3)[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([Cl:36])[CH:21]=3)[N:16]=2)[C:11](=C=O)[CH2:10]1)C>O>[C:1]([CH:2]1[CH2:14][CH2:13][N:12]([C:15]2[N:24]=[C:23]([NH:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]4[O:33][CH2:34][O:35][C:29]=4[CH:28]=3)[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([Cl:36])[CH:21]=3)[N:16]=2)[CH2:11][CH2:10]1)([OH:4])=[O:3]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 867499922-(4-Ethoxy-carbonylpiperidino)-4-(3,4-methylenedioxybenzyl)amino-6-chloroquinazoline

생성물 1

HCID 53114861-(6-Chloro-4-(3,4-methylenedioxybenzyl)aminoquinazolin-2-yl)piperidine-4-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

10 ml of ethanol, 5 ml of water and 820 mg of sodium hydroxide were added to 1 g of 2-(4-ethoxy-carbonylpiperidino)-4-(3,4-methylenedioxybenzyl)amino-6-chloroquinazoline. The obtained mixture was refluxed for 20 minutes, concentrated under a reduced pressure and neutralized with 1N hydrochloric acid. The crystals thus precipitated were recovered by filtration to give 920 mg of the title compound.

후처리

  1. temperatureThe obtained mixture was refluxed for 20 minutes
  2. concentrationconcentrated under a reduced pressure and neutralized with 1N hydrochloric acid
  3. customThe crystals thus precipitated
  4. filtrationwere recovered by filtration

출처 및 근거

ORD 기록
ord-94ab31acca5a4b53ac2e7a80ed7e9242
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05576322

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