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Diazomethane → 2,3,6,7,8,9-Hexahydro-2-methoxymethyl-5-methylfuro-[2,3-f]quinoline-7-one

HRID 1900721
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인쇄 미리보기

반응식

HRID 1900721 반응식
[OH:1][CH2:2][CH:3]1[O:17][C:6]2=[C:7]3[C:12](=[C:13]([CH3:15])[CH:14]=[C:5]2[CH2:4]1)[NH:11][C:10](=[O:16])[CH2:9][CH2:8]3.[N+](=[CH2:20])=[N-]>O1CCCC1.CCOCC>[CH3:20][O:1][CH2:2][CH:3]1[O:17][C:6]2=[C:7]3[C:12](=[C:13]([CH3:15])[CH:14]=[C:5]2[CH2:4]1)[NH:11][C:10](=[O:16])[CH2:9][CH2:8]3
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참가 물질

5

반응물 2

HCID 9550DiazomethaneHCID 233697232,3,6,7,8,9-Hexahydro-2-hydroxymethyl-5-methylfuro[2,3-f]quinoline-7-one

생성물 1

HCID 233695592,3,6,7,8,9-Hexahydro-2-methoxymethyl-5-methylfuro-[2,3-f]quinoline-7-one수율 88%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2,3,6,7,8,9-hexahydro-2-hydroxymethyl -5-methylfuro-[2,3-f]quinoline-7-one (300 mg) in tetrahydrofuran (100 ml), silica gel (10 g) and a solution of diazomethane in ether (200 ml) were added, and stirred at room temperature for 36 hours. After completion of the reaction, the solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 280 mg of the target product as a pale yellow powder (88%).

후처리

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off
  3. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-5075a3aa231b46298c541fe949785e92
출처 데이터셋
uspto-grants-1996_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05576324

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