8-Methyl-7-nitroquinoline → HCID 14115670, 화합물

HRID 1901241노트

반응식

HRID 1901241 반응식
[CH3:1][C:2]1[C:3]([N+:12]([O-])=O)=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:12][C:3]1[C:2]([CH3:1])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 2541658-Methyl-7-nitroquinolineHCID 2723923Ammonium formate

생성물 1

HCID 14115670HCID 14115670, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 8-methyl-7-nitroquinoline (1.8 g) in methanol (20 mL)is added Pd/C (10%, 0.45 g) and ammonium formate (2.77 g). The mixture is stirred at room temperature for 30 minutes, then filtered on Celite, with methanol wash of the solids. The filtrate is rotary evaporated and the residue partitioned between H2O and CH2Cl2. The organic layer is dried over potassium carbonate, filtered and rotary evaporated to afford 7-amino-8-methylquinoline as a yellow solid.

후처리

  1. filtrationfiltered on Celite, with methanol
  2. washwash of the solids
  3. customThe filtrate is rotary evaporated
  4. customthe residue partitioned between H2O and CH2Cl2
  5. dry with materialThe organic layer is dried over potassium carbonate
  6. filtrationfiltered
  7. customrotary evaporated

출처 및 근거

ORD 기록
ord-919c70c680954da5b67fc9d1a2bd54de
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05576437

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