Hydrochloric Acid → 3-(2-Amino-3-methylaminocarbonyloxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride

HRID 1901612노트

반응식

HRID 1901612 반응식
CC(O)C.Cl.C(OC([NH:13][CH:14]([CH2:27][O:28][C:29]([NH:31][CH3:32])=[O:30])[CH2:15][O:16][C:17]1[C:21]2[CH:22]=[C:23]([Cl:26])[CH:24]=[CH:25][C:20]=2[O:19][N:18]=1)=O)(C)(C)C>CO>[ClH:26].[NH2:13][CH:14]([CH2:27][O:28][C:29]([NH:31][CH3:32])=[O:30])[CH2:15][O:16][C:17]1[C:21]2[CH:22]=[C:23]([Cl:26])[CH:24]=[CH:25][C:20]=2[O:19][N:18]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3776Isopropanol2회HCID 23368486HCID 23368486, 화합물

생성물 1

HCID 233684343-(2-Amino-3-methylaminocarbonyloxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In 10 ml of methanol is dissolved 3-(2-tert-butoxycarbonylamino-3-methylaminocarbonyloxypropoxy)-5-chloro-1,2-benzoisoxazole, and to this solution is added 9.6 ml of a 2-propanol solution (7.5N) of hydrogen chloride, and they are subjected to reaction at 20°-25° C. for 4.5 hours. The solvent is removed from the reaction mixture by distillation under reduced pressure, and to the residue obtained is added 5 ml of 2-propanol, after which the crystals precipitated are collected by filtration, to obtain 0.30 g of colorless, crystalline 3-(2-amino-3-methylaminocarbonyloxypropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride having a melting point of 206°-209° C.

후처리

  1. customare subjected to reaction at 20°-25° C. for 4.5 hours
  2. customThe solvent is removed from the reaction mixture by distillation under reduced pressure
  3. customto the residue obtained
  4. customafter which the crystals precipitated
  5. filtrationare collected by filtration

출처 및 근거

ORD 기록
ord-303b994a51634e5d92f9986586fbfa76
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05578627

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