L-Methionine → N-[(2-Aminophenyl)methyl]-L-methionine

HRID 1902394노트

반응식

HRID 1902394 반응식
[CH:1](=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[NH2:10][C@H:11]([C:16]([OH:18])=[O:17])[CH2:12][CH2:13][S:14][CH3:15].C(=O)([O-])[O-].[Na+].[Na+].[BH4-].[Na+]>O>[NH2:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[CH2:1][NH:10][C@H:11]([C:16]([OH:18])=[O:17])[CH2:12][CH2:13][S:14][CH3:15]

참가 물질

6

반응물 4

HCID 6137L-MethionineHCID 10340Sodium CarbonateHCID 682552-AminobenzaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 13340364N-[(2-Aminophenyl)methyl]-L-methionine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 0.1 mol of anthranil aldehyde, 0.1 mol of methionine and a solution of 0.1 mol of sodium carbonate in 50 ml of water was stirred for a few hours. After everything had gone into solution, 0.1 mol of sodium borohydride was added, and the mixture was stirred at room temperature for 12 hours. The reaction solution was then acidified to pH3, and the precipitate was collected and dried, yielding 85% of theory of N-(2-amino-benzyl)-methionine, m.p. 198° C. The total yield, based on the anthranilic acid starting material, was 68% of theory.

후처리

  1. additionwas added
  2. customthe precipitate was collected
  3. customdried

출처 및 근거

ORD 기록
ord-a394203afa7c4ba28ada684d91a0a6c7
출처 데이터셋
uspto-grants-1982_12
특허 번호
US04363766

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