1,6-Dibromohexane → 6-Phenoxyhexyl bromide

HRID 1902491노트

반응식

[C:1]1([O-:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].[Br:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]Br>>[O:7]([CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][Br:9])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

반응물 2

HCID 123681,6-Dibromohexane

HCID 4445035Phenolate Sodium

생성물 1

HCID 1428786-Phenoxyhexyl bromide수율 77%

실험 절차

Preparation analogously to Example 38 by the reaction of sodium phenolate with 1,6-dibromohexane to give 6-phenoxy-1-bromohexane (b.p.11 =172°-5°; yield 77%), which is reacted with excess 5-amino-5-desoxy-1.4;3.6-dianhydro-L-iditol 2-nitrate. Isolation as hydrochloride. Yield, after recrystallisation from isopropanol: 53%.

후처리

customPreparation analogously to Example 38

출처 및 근거

ORD 기록: ord-f472639537c04c3fa55e0c1542f63088
출처 데이터셋: uspto-grants-1982_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04363805

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