Trifluoroacetic acid → HCID 12873978, 화합물

HRID 1902636노트

반응식

HRID 1902636 반응식
[F:1][C:2]([F:7])([F:6])[C:3](O)=O.[BH4-].[Na+].[N:10]1[CH2:11][CH2:12][N:13]2[C:17]3[CH:18]=[C:19]([NH2:22])[CH:20]=[CH:21][C:16]=3[S:15][C:14]=12>>[F:1][C:2]([F:7])([F:6])[CH2:3][NH:22][C:19]1[CH:20]=[CH:21][C:16]2[S:15][C:14]3=[N:10][CH2:11][CH2:12][N:13]3[C:17]=2[CH:18]=1

참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 6586872,3-Dihydroimidazo(2,1-b)benzothiazol-6-amineHCID 4311764Sodium borohydride

생성물 1

HCID 12873978HCID 12873978, 화합물

실험 절차

To a stirred mixture of 60 parts of trifluoroacetic acid and 4 parts of sodium borohydride are added portionwise, during a 5 hours-period, 4 parts of 2,3-dihydroimidazo[2,1-b]benzothiazol-6-amine at 30°-40° C. The reaction mixture is poured onto 300 parts of ice-water. The precipitated product is filtered off, washed with water and taken up in trichloromethane. The mixture is washed with ammonium hydroxide. The organic phase is dried, filtered and evaporated. The residue is crystallized from acetonitrile, yielding 3.3 parts of 2,3-dihydro-N-(2,2,2-trifluoroethyl)imidazo[2,1-b]benzothiazol-6-amine; mp. 211.7° C.

후처리

  1. filtrationThe precipitated product is filtered off
  2. washwashed with water
  3. washThe mixture is washed with ammonium hydroxide
  4. customThe organic phase is dried
  5. filtrationfiltered
  6. customevaporated
  7. customThe residue is crystallized from acetonitrile

출처 및 근거

ORD 기록
ord-bfafc5cf105b419087c86dfbc2a20f80
출처 데이터셋
uspto-grants-1982_12
특허 번호
US04364942

반응 노트

불러오는 중…