Methyl p-toluenesulfonate → 2-Fluoro-1-methylpyridinium p-toluenesulfonate

반응식

[CH3:1][O:2][S:3]([C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][CH:7]=1)(=[O:5])=[O:4].[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1>>[S:3]([C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][CH:7]=1)([O-:5])(=[O:4])=[O:2].[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N+:15]=1[CH3:1]

참가 물질

반응물 2

HCID 6645Methyl p-toluenesulfonate

HCID 97462-Fluoropyridine

생성물 1

HCID 1716312-Fluoro-1-methylpyridinium p-toluenesulfonate수율 95%

실험 절차

2-fluoro-1-methylpyridinium tosylate is prepared by adding 18.6 g (0.1 mol.) of paratoluen sulphonate methyl ester to 9.7 g (0.1 mol.) of 2-fluoropyridine, heating the resultant mixture for about 20 minutes at 120° C. and cooling the heated mixture to yield 25 g of crystalline 2-fluoro-1-methylpyridinium tosylate (95%). This crystalline starting material is subsequently washed with ether and then dried.

후처리

custom2-fluoro-1-methylpyridinium tosylate is prepared
temperaturecooling the heated mixture

출처 및 근거

ORD 기록: ord-073630c234b4488e8a0ae44a4bae84a0
출처 데이터셋: uspto-grants-1982_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04365067

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