Sodium Hydroxide → 2-Pyrrolidinone, 1-(8-quinolinyl)-

HRID 1902824

반응식

HRID 1902824 반응식
Cl[CH2:2][CH2:3][CH2:4][C:5]([NH:7][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:17]=1[N:16]=[CH:15][CH:14]=[CH:13]2)=[O:6].[OH-].[Na+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(Cl)Cl>[N:16]1[C:17]2[C:12](=[CH:11][CH:10]=[CH:9][C:8]=2[N:7]2[CH2:2][CH2:3][CH2:4][C:5]2=[O:6])[CH:13]=[CH:14][CH:15]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 128985464-chloro-N-(8-quinolyl)butyramide

생성물 1

HCID 30614652-Pyrrolidinone, 1-(8-quinolinyl)-수율 90%

시약·촉매·용매 2

HCID 66133Benzyl triethylammonium chloride촉매HCID 6344Dichloromethane용매2회

실험 절차

A solution of 4-chloro-N-(8-quinolyl)butyramide (2.5 g, 0.01 mole) and benzyltriethyl ammonium chloride (0.115 g, 5 mole%) in methylene chloride (30 ml) was stirred at room temperature. A solution of 30% aqueous sodium hydroxide (10 ml) was added and the mixture was stirred for 16 hours. The reaction mixture was then diluted with methylene chloride, the organic layer was drawn off and washed with a saturated salt solution, dried over sodium sulphate and evaporated to a solid residue. The residue was recrystallized from methylene chloride/petroleum ether to afford 1-(8-quinolyl)-2-pyrrolidinone which was identical by tlc and NMR in comparison with the product of Example 1, yield 90%.

후처리

  1. washwashed with a saturated salt solution
  2. dry with materialdried over sodium sulphate
  3. customevaporated to a solid residue
  4. customThe residue was recrystallized from methylene chloride/petroleum ether

출처 및 근거

ORD 기록
ord-5e46261967d34ef6bd36697eb14215cf
출처 데이터셋
uspto-grants-1982_12
특허 번호
US04366158

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