Acetic Acid → HCID 178491905, 화합물

HRID 1902870노트

반응식

HRID 1902870 반응식
C([O:8][N:9]1[CH2:13][CH2:12][NH:11][C:10]1=[N:14][C:15]1[C:20]([Cl:21])=[CH:19][C:18]([O:22][CH3:23])=[CH:17][C:16]=1[Cl:24])C1C=CC=CC=1.C(O)(=O)C.C(Cl)C1C=CC=CC=1>C(O)C.[Pt]=O>[Cl:21][C:20]1[CH:19]=[C:18]([O:22][CH3:23])[CH:17]=[C:16]([Cl:24])[C:15]=1[N:14]=[C:10]1[NH:11][CH2:12][CH2:13][N:9]1[OH:8]

참가 물질

6

반응물 3

HCID 176Acetic AcidHCID 7503Benzyl ChlorideHCID 178491903HCID 178491903, 화합물

생성물 1

HCID 178491905HCID 178491905, 화합물

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

44.3 g of 1-(benzyloxy)-2-[(2,6-dichloro-4-methoxyphenyl)imino]imidazoline are dissolved in 350 ml of ethanol and 350 ml of acetic acid and treated with 13.8 ml of benzyl chloride. The mixture is hydrogenated in the presence of 1 g of platinum oxide under normal pressure. After completion of the hydrogen uptake, the catalyst is removed by filtration and the solution is evaporated. The residue is treated with water and washed with ether. The aqueous phase is made alkaline and extracted with ethyl acetate. After drying and evaporating the organic extracts and recrystallization of the residue from ethyl acetate/methanol, there is obtained 2-[(2,6-dichloro-4-methoxyphenyl)imino]-1-hydroxyimidazolidine of melting point 199°-201°.

후처리

  1. customAfter completion of the hydrogen uptake, the catalyst is removed by filtration
  2. customthe solution is evaporated
  3. additionThe residue is treated with water
  4. washwashed with ether
  5. extractionextracted with ethyl acetate
  6. customAfter drying
  7. customevaporating
  8. customthe organic extracts and recrystallization of the residue from ethyl acetate/methanol

출처 및 근거

ORD 기록
ord-2254b4e03a2a4ccfa4ae54578cf782f3
출처 데이터셋
uspto-grants-1982_12
특허 번호
US04366160

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