Formamide → HCID 14456868, 화합물

HRID 1903012노트

반응식

HRID 1903012 반응식
[CH3:1][O:2][C:3]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:4]=1[CH2:5][N:6]1[CH:9]([CH2:10]I)[CH2:8][C:7]1=[O:12].[CH:19]([NH2:21])=O.[C-]#N.[Na+]>>[C:19]([CH2:10][CH:9]1[N:6]([CH2:5][C:4]2[CH:13]=[CH:14][C:15]([O:17][CH3:18])=[CH:16][C:3]=2[O:2][CH3:1])[C:7](=[O:12])[CH2:8]1)#[N:21]

참가 물질

4

반응물 3

HCID 713FormamideHCID 8929Sodium CyanideHCID 14456867HCID 14456867, 화합물

생성물 1

HCID 14456868HCID 14456868, 화합물수율 70%

실험 절차

A solution of 1.2 g. (3.3 mmoles) of 1-(2,4-dimethoxybenzyl)-4-(iodomethyl)-2-azetidinone prepared according to Example 13 in 5 ml. ofddimethyl formamide is stirred with 0.35 g. (7 mmoles) of sodium cyanide for 48 hours, at room temperature. The solution is then poured onto 30 ml. of water and extracted with five 20-ml. portions of ether. The ethereal solution is dried with magnesium sulfate, decolored with activated carbon, filtered and the filtrate is evaporated in vacuo. 0.6 g. (70%) of the named compound are obtained.

후처리

  1. customat room temperature
  2. additionThe solution is then poured onto 30 ml
  3. extractionof water and extracted with five 20-ml
  4. dry with materialThe ethereal solution is dried with magnesium sulfate
  5. filtrationfiltered
  6. customthe filtrate is evaporated in vacuo

출처 및 근거

ORD 기록
ord-1b7ff7b5be72475fb29a4d64ec6d74b3
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04435322

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