Hydrochloric Acid → HCID 568802, 화합물

HRID 1903015노트

반응식

HRID 1903015 반응식
[C:1]1([N:7]2[C:10](=[O:11])[CH2:9][CH:8]2[C:12](OCC)=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.P([O-])([O-])(O)=O.[Na+].[Na+]>CO>[C:1]1([N:7]2[CH:8]([CH2:12][OH:13])[CH2:9][C:10]2=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 24203Sodium Phosphate, DibasicHCID 12479106HCID 12479106, 화합물

생성물 1

HCID 568802HCID 568802, 화합물수율 76%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a dilution of 106.5 g. (0.486 moles) of ethyl 1-phenyl-4-oxo-2-azetidine-carboxylate prepared according to Example 24 in 700 ml. of methanol 18.74 g. (0.493 moles) of sodium tetrahydrido-borate(III) are added with outer cooling with ice water and stirring. The mixture is acidified with dilute hydrochloric acid and it is then neutralized with disodium hydrogenphosphate. Methanol is distilled off in vacuo. 65 g. (76%) of the named compound are obtained, melting at 100° to 102° C. (ethyl acetate/petroleum ether).

후처리

  1. distillationMethanol is distilled off in vacuo

출처 및 근거

ORD 기록
ord-7156552f74684ac7bda19e085ce9e4ce
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04435322

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