Sodium Chloride → 3-((tert-Butoxycarbonyl)amino)-4,4-difluorobutanoic acid

HRID 1903249

반응식

HRID 1903249 반응식
Cl.[F:2][CH:3]([F:10])[CH:4]([NH2:9])[CH2:5][C:6]([OH:8])=[O:7].[C:11](OC([O-])=O)([O-])=O.[C:18](=[O:21])(O)[O-:19].[Na+].[Cl-].[Na+].O1[CH2:29][CH2:28][CH2:27]C1>O>[F:2][CH:3]([F:10])[CH:4]([NH:9][C:18]([O:19][C:28]([CH3:27])([CH3:29])[CH3:11])=[O:21])[CH2:5][C:6]([OH:8])=[O:7]

참가 물질

7

반응물 5

HCID 5234Sodium ChlorideHCID 8028TetrahydrofuranHCID 516892Sodium BicarbonateHCID 15238643PyrocarbonateHCID 714030983-Amino-4,4-difluorobutanoic acid hydrochloride

생성물 1

HCID 204684533-((tert-Butoxycarbonyl)amino)-4,4-difluorobutanoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 4,4-difluoro-3-amino-butanoic acid, hydrochloride prepared as in Step C (0.702 g, 4 mM), ditertiobutyl dicarbonate (0.916 g, 4.2 mM), sodium bicarbonate (0.336 g, 4 mM) in tetrahydrofuran and water (6 ml of a 1:1 mixture) is heated at reflux for 48 hours. The resulting solution is saturated with sodium chloride and extracted three times with chloroform. The organic phase is dried over anhydrous magnesium sulfate, and the solvent evaporated in vacuo yielding a colorless oil.

후처리

  1. temperatureis heated
  2. temperatureat reflux for 48 hours
  3. extractionextracted three times with chloroform
  4. dry with materialThe organic phase is dried over anhydrous magnesium sulfate
  5. customthe solvent evaporated in vacuo
  6. customyielding a colorless oil

출처 및 근거

ORD 기록
ord-e51cfa98c7f84b508c523cc99e55a595
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04435425

연결된 노트

불러오는 중…