Benzyl Chloride → 2-Amino-5-dibenzylaminomethylpyrrolo[2,3-d]pyrimidin-4-one

HRID 1903314노트

반응식

HRID 1903314 반응식
[NH2:1][C:2]1[N:7]=[C:6]2[N:8]=[CH:9][C:10]([CH2:11][NH:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[C:5]2[C:4](=[O:20])[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:27](Cl)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>CO.[I-].[Na+]>[NH2:1][C:2]1[N:7]=[C:6]2[N:8]=[CH:9][C:10]([CH2:11][N:12]([CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[C:5]2[C:4](=[O:20])[N:3]=1

참가 물질

6

반응물 3

HCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 204685402-Amino-5-benzylaminomethylpyrrolo[2,3-d]pyrimidin-4-one

생성물 1

HCID 202463722-Amino-5-dibenzylaminomethylpyrrolo[2,3-d]pyrimidin-4-one수율 24.9%

시약·촉매·용매 2

HCID 5238Sodium Iodide촉매HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

In 30 ml of methanol was dissolved 172 mg of 2-amino-5-benzylaminomethylpyrrolo[2,3-d]pyrimidin-4-one (the compound of Example 4), followed by addition of 90 mg of anhydrous potassium carbonate, 2 mg of sodium iodide and 81 mg of benzyl chloride. The mixture was stirred on a water bath at 60° C. for 4 hrs. The solvent was then distilled off and the residue was purified by silica gel column chromatography to give 57 mg of the desired compound.

후처리

  1. distillationThe solvent was then distilled off
  2. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-502030615bf548bc96bcac359d882794
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04435569

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