Hexanal → Tert-butyl 3-hydroxyoctanoate

HRID 1903523노트

반응식

HRID 1903523 반응식
[CH:1](=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].Br[CH2:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11]>[Zn]>[OH:7][CH:1]([CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[CH2:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11]

참가 물질

4

반응물 2

HCID 6184HexanalHCID 79177tert-Butyl bromoacetate

생성물 1

HCID 20467271Tert-butyl 3-hydroxyoctanoate수율 77.2%

시약·촉매·용매 1

HCID 23994Zinc촉매

실험 절차

The reaction of hexanal (720 mg) and tert-butyl bromoacetate (2.265 g) was carried out under the presence of zinc (850 mg) according to similar manner to that of Preparation 1-(1) to afford an oil of tert-butyl 3-hydroxyoctanoate (1.2 g).

후처리

  1. customof Preparation 1-(1)

출처 및 근거

ORD 기록
ord-5cdba11fa8984890ad8d24d9ed81c983
출처 데이터셋
uspto-grants-1984_03
특허 번호
US04436726

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