Ethyl 7-chloro-1H-pyrazolo[4,3-B]pyridine-6-carboxylate → ethyl 7-n-butylamino-1H-pyrazolo [4,3-b]pyridine-6-carboxylate
반응식
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]2[CH:13]=[N:14][NH:15][C:3]=12>C(N)CCC>[CH2:4]([NH:5][C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]2[CH:13]=[N:14][NH:15][C:3]=12)[CH2:3][CH2:2][CH3:7]참가 물질
3
실험 절차
Ethyl 7-chloro-1H-pyrazolo[4,3-b]pyridine-6-carboxylate (3.5 g, 15.5 mmol) was dissolved in n-butylamine (25 ml) and stirred at room temperature for 3 h. Excess butylamine was removed in vacuo and the residual solid was washed well with water, and recrystallised from ethyl acetate to give ethyl 7-n-butylamino-1H-pyrazolo [4,3-b]pyridine-6-carboxylate (2.75 g, 67%), m.p. 164°-170° C.
후처리
- customExcess butylamine was removed in vacuo
- washthe residual solid was washed well with water
- customrecrystallised from ethyl acetate
출처 및 근거
- ORD 기록
- ord-c7eda3542d964d179234801c23ff0d71
- 출처 데이터셋
- uspto-grants-1989_06
- 특허 번호
- US04837238
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