Benzoyl Peroxide → Ethyl 4-(bromomethyl)-2-chlorobenzoate

HRID 1904413노트

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HRID 1904413 반응식
[Cl:1][C:2]1[CH:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[Br:14]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:14][CH2:13][C:11]1[CH:10]=[CH:9][C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])=[C:2]([Cl:1])[CH:12]=1

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 14459377Benzoic acid, 2-chloro-4-methyl-, ethyl ester

생성물 1

HCID 14459378Ethyl 4-(bromomethyl)-2-chlorobenzoate

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of ethyl 2-chloro-4-methylbenzoate (2.34 g, 0.0118 mol), N-bromosuccinimide (2.05 g, 0.0115 mol), and benzoyl peroxide (0.5 g) in carbon tetrachloride (50 ml) was heated under reflux for 90 minutes. The resulting solution was filtered and the solvent was evaporated off under reduced pressure to yield ethyl 4-(bromomethyl)-2-chlorobenzoate as a yellow crystalline solid having the following structural characteristics:

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 90 minutes
  3. filtrationThe resulting solution was filtered
  4. customthe solvent was evaporated off under reduced pressure

출처 및 근거

ORD 기록
ord-144559fac48f445fa7c30663345cfb4e
출처 데이터셋
uspto-grants-1989_06
특허 번호
US04837333

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