Hydrochloric Acid → 2-(1-Benzylpiperidin-4-yl)acetic acid hydrochloride

HRID 1904810노트

반응식

HRID 1904810 반응식
[ClH:1].[C:2]1([CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([CH2:15][C:16]([O:18]CC)=[O:17])[CH2:11][CH2:10]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>>[ClH:1].[C:2]1([CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([CH2:15][C:16]([OH:18])=[O:17])[CH2:11][CH2:10]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 13349687Ethyl 1-(phenylmethyl)-4-piperidineacetate hydrochloride

생성물 1

HCID 140128442-(1-Benzylpiperidin-4-yl)acetic acid hydrochloride

실험 절차

A mixture of 8 parts of ethyl 1-(phenylmethyl)-4-piperidineacetate hydrochloride and 80 parts of a dilute hydrochloric acid solution was stirred and refluxed for 4 hours. After cooling, the reaction mixture was evaporated. The residue was washed with 2-propanone and the solvent was evaporated again. The solid residue was washed with 2-propanone, filtered off and dried, yielding 6 parts of 1-(phenylmethyl)-4-piperidineacetic acid hydrochloride; mp. 137°-145° C. (2).

후처리

  1. temperaturerefluxed for 4 hours
  2. temperatureAfter cooling
  3. customthe reaction mixture was evaporated
  4. washThe residue was washed with 2-propanone
  5. customthe solvent was evaporated again
  6. washThe solid residue was washed with 2-propanone
  7. filtrationfiltered off
  8. customdried

출처 및 근거

ORD 기록
ord-0f01a6b307a745dc890042754805a2b3
출처 데이터셋
uspto-grants-1989_06
특허 번호
US04839374

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