Hydrochloric Acid → (2RS, 3S)-3-amino-2-hydroxy-5-methylhexyl methyl ether hydrochloride

HRID 1905321노트

반응식

HRID 1905321 반응식
[CH3:1][O:2][CH2:3][CH:4]([OH:21])[C@@H:5]([NH:10]C(OCC1C=CC=CC=1)=O)[CH2:6][CH:7]([CH3:9])[CH3:8].[ClH:22]>CO.[Pd]>[ClH:22].[CH3:1][O:2][CH2:3][CH:4]([OH:21])[C@@H:5]([NH2:10])[CH2:6][CH:7]([CH3:9])[CH3:8]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 13909435(2RS, 3S)-3-carbobenzoxyamino-2-hydroxy-5-methylhexyl methyl ether

생성물 1

HCID 86743183(2RS, 3S)-3-amino-2-hydroxy-5-methylhexyl methyl ether hydrochloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 94 mg of the ether compound obtained in 10 ml of methanol was added 0.16 ml of a 2N-hydrochloric acid, and the mixture was hydrogenated over 10 mg of a 10% palladium charcoal under hydrogen atmosphere. After filtration of the catalyst, the filtrate was evaporated under reduced pressure to obtain 54 mg of (2RS, 3S)-3-amino-2-hydroxy-5-methylhexyl methyl ether hydrochloride as a colorless viscous oil.

후처리

  1. filtrationAfter filtration of the catalyst
  2. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-c156175a9a7544e6b452522edbcaa4e9
출처 데이터셋
uspto-grants-1989_06
특허 번호
US04841067

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