Benzoyl chloride → HCID 13670754, 화합물
반응식
[NH2:1][C:2]1[S:3][C:4]2[CH2:10][CH:9]([N:11]([CH3:13])[CH3:12])[CH2:8][CH2:7][C:5]=2[N:6]=1.[C:14]([Cl:22])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>N1C=CC=CC=1>[ClH:22].[ClH:22].[C:14]([NH:1][C:2]1[S:3][C:4]2[CH2:10][CH:9]([N:11]([CH3:13])[CH3:12])[CH2:8][CH2:7][C:5]=2[N:6]=1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1참가 물질
4
실험 절차
3.0 g (15 mMol) of 2-amino-6-dimethylamino-4,5,6,7-tetrahydro-benzthiazole are dissolved in 15 ml of pyridine and 2.1 g (15 mMol) of benzoylchloride are added dropwise. After standing overnight the mixture is concentrated, mixed with soda solution and extracted with chloroform. The chloroform extract is concentrated and then chromatographed on silica gel (eluant: methylenechloride/methanol=9/1). The isolated base (melting point 174° C.) is dissolved in acetone and the dihydrochloride is precipitated with isopropanolic hydrochloric acid.