Hydrochloric Acid → Ethyl 2-amino-3-cyanothieno[3,2-b]thiophene-5-carboxylate

HRID 1905461노트

반응식

HRID 1905461 반응식
CN(C)C=[N:4][C:5]1[S:9][C:8]2[CH:10]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[S:12][C:7]=2[C:6]=1[C:18]#[N:19].Cl>C(O)C>[NH2:4][C:5]1[S:9][C:8]2[CH:10]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[S:12][C:7]=2[C:6]=1[C:18]#[N:19]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68115437N,N-dimethyl-N'-(3-cyano-5-ethoxycarbonylthieno[3,2-b]thien-2-yl)formamidine

생성물 1

HCID 14047327Ethyl 2-amino-3-cyanothieno[3,2-b]thiophene-5-carboxylate수율 80%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 319 parts of N,N-dimethyl-N'-(3-cyano-5-ethoxycarbonylthieno[3,2-b]thien-2-yl)formamidine, 2,000 parts of ethanol and 210 parts of concentrated hydrochloric acid was heated at the boil for 1 hour. After cooling down, the precipitate was filtered off with suction, washed with methanol and then with water and dried. This gave 210 parts (80% of theory) of ethyl 2-amino-3-cyanothieno[3,2-b]thiophene-5-carboxylate.

후처리

  1. temperaturewas heated at the boil for 1 hour
  2. temperatureAfter cooling down
  3. filtrationthe precipitate was filtered off with suction
  4. washwashed with methanol
  5. dry with materialwith water and dried

출처 및 근거

ORD 기록
ord-894e8660d7ff4f9e815905a35f0f61ab
출처 데이터셋
uspto-grants-1989_06
특허 번호
US04843153

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