2-[4-(Benzyloxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]acetamide → Oxiracetam

HRID 1905547노트

반응식

HRID 1905547 반응식
C([O:8][C:9]1[CH2:13][N:12]([CH2:14][C:15]([NH2:17])=[O:16])[C:11](=[O:18])[CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)(=O)C.[Pd].[Pt]=O>[OH:8][CH:9]1[CH2:13][N:12]([CH2:14][C:15]([NH2:17])=[O:16])[C:11](=[O:18])[CH2:10]1

참가 물질

6

반응물 2

HCID 142744722-[4-(Benzyloxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]acetamide2회HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 4626Oxiracetam

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 82844Platinum oxide (PtO)촉매HCID 176Acetic Acid용매

실험 절차

Catalytic hydrogenolysis and hydrogenation of 4-benzyloxy-3-pyrrolin-2-on-1-yl acetamide 3.00 g of 4-benzyloxy-3-pyrrolin-2-on-1-yl acetamide was dissolved in 30 ml of concentrated acetic acid and mixed with 240 mg of palladium 5 percent on activated carbon and 24 mg of platinum oxide. Hydrogenolysis and hydrogenation at 15 bars of hydrogen pressure and room temperature were performed for 65 hours. Then filtering off from the catalyst and evaporation of the solvent were performed. The residue was picked up in H2O and allowed to run over 5.0 g of weakly basic ion exchanger. The water was distilled off and the residue mixed with 10 ml of acetone. 1.53 g of nearly white 4-hydroxypyrrolidin-2-on-1-yl acetamide with a melting point of 163.5° to 165.7° C. was obtained.

후처리

  1. filtrationThen filtering off from the catalyst and evaporation of the solvent
  2. distillationThe water was distilled off
  3. additionthe residue mixed with 10 ml of acetone

출처 및 근거

ORD 기록
ord-1ec0859131be4dbbb5b33508ae58bf95
출처 데이터셋
uspto-grants-1989_06
특허 번호
US04843166

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