4,6-Dichloro-5-nitro-2-phenylpyrimidine → 4,6-Dichloro-2-phenylpyrimidin-5-amine

HRID 1905842

반응식

HRID 1905842 반응식
[Cl:1][C:2]1[C:7]([N+:8]([O-])=O)=[C:6]([Cl:11])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:3]=1>CCOCC.C([O-])(=O)C.[Ni]>[NH2:8][C:7]1[C:2]([Cl:1])=[N:3][C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:5][C:6]=1[Cl:11]

참가 물질

4

반응물 1

HCID 1006444,6-Dichloro-5-nitro-2-phenylpyrimidine

생성물 1

HCID 7366734,6-Dichloro-2-phenylpyrimidin-5-amine수율 72.5%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 21226428Ether acetate용매

실험 절차

27.0 g of 4,6-dichloro-5-nitro-2-phenylpyrimidine are hydrogenated in ether acetate at room temperature by treatment with Raney nickel. The catalyst is afterwards separated and the reaction solution is concentrated by evaporation. Crystallisation of the residue from petroleum ether then yields 17.4 g of 5-amino-4,6-dichloro-2-phenylpyrimidine, m.p. 143°-144° C. (compound No. 1).

후처리

  1. customThe catalyst is afterwards separated
  2. concentrationthe reaction solution is concentrated by evaporation
  3. customCrystallisation of the residue from petroleum ether

출처 및 근거

ORD 기록
ord-0585826f0ec546e39554c0e3decd9b03
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04648896

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