Dimethyl(methylene)ammounium iodide → 2-[2-(5-Dimethylaminomethyl-2-thienylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone

HRID 1905893노트

반응식

HRID 1905893 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][S:7][CH2:8][CH2:9][NH:10][C:11]1[NH:16][C:15](=[O:17])[C:14]([CH2:18][C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)=[CH:13][N:12]=1.[I-].[CH3:26][N+:27]([CH3:29])=[CH2:28]>CN(C)C=O>[CH3:26][N:27]([CH2:29][C:5]1[S:1][C:2]([CH2:6][S:7][CH2:8][CH2:9][NH:10][C:11]2[NH:16][C:15](=[O:17])[C:14]([CH2:18][C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)=[CH:13][N:12]=2)=[CH:3][CH:4]=1)[CH3:28]

참가 물질

4

반응물 2

HCID 2724133Dimethyl(methylene)ammounium iodideHCID 135052962-[2-(2-Thienylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone

생성물 1

HCID 135053002-[2-(5-Dimethylaminomethyl-2-thienylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-[2-(2-Thienylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone is reacted with an excess of dimethyl(methylene)ammonium iodide in dimethylformamide at room temperature to give 2-[2-(5-dimethylaminomethyl-2-thienylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone.

출처 및 근거

ORD 기록
ord-fdb2d8b9cfb843f69b1f1328059b5cdf
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04649141

반응 노트

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