Acetic Anhydride → 3-Acetylamino-1-benzyl-4-methylpyrrolidine

반응식

[NH2:1][CH:2]1[CH:6]([CH3:7])[CH2:5][N:4]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:3]1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[C:15]([NH:1][CH:2]1[CH:6]([CH3:7])[CH2:5][N:4]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:3]1)(=[O:17])[CH3:16]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 142112411-Benzyl-4-methylpyrrolidin-3-amine

생성물 1

HCID 202133753-Acetylamino-1-benzyl-4-methylpyrrolidine

실험 절차

3-Amino-1-benzyl-4-methylpyrrolidine (Japanese Laid-Open Patent Publication No. 22699/1980) was allowed to react with acetic anhydride to give 3-acetylamino-1-benzyl-4-methylpyrrolidine; IR 3300, 1650 cm-1. This compound was hydrogenated catalytically in the presence of 5% palladium-carbon to give 3-acetylamino-4-methylpyrrolidine as an oil.

출처 및 근거

ORD 기록: ord-708c2b3e03a4469e871171616fa90154
출처 데이터셋: uspto-grants-1987_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04649144

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