Chloroacetic Acid → 2-(2,4-Difluorophenyl)ethoxyacetic acid
반응식
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5][OH:6].Cl[CH2:13][C:14]([OH:16])=[O:15]>>[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5][O:6][CH2:13][C:14]([OH:16])=[O:15]참가 물질
3
반응 조건
- 온도
- 120 °C
실험 절차
3.63 g of 2,4-difluorophenethyl alcohol were reacted with 2.17 g of chloroacetic acid in a manner analogous to that described in Example 1(a), except that the reaction mixture was heated at 120° C. for 1 hour, to give 2.7 g (54%) of 2-(2,4-difluorophenyl)ethoxyacetic acid in the form of an oil which was homogeneous according to chromatography.
출처 및 근거
- ORD 기록
- ord-1af4a45575fc4ec6904e5fe919aa2779
- 출처 데이터셋
- uspto-grants-1987_03
- 특허 번호
- US04649160
반응 노트
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