Sodium Hydroxide → 2-Amino-5-(pyridin-4-yl)-1,3-thiazole-4-carboxylic acid

HRID 1906006노트

반응식

HRID 1906006 반응식
[NH2:1][C:2]1[S:3][C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:5]([C:7]([O:9]CC)=[O:8])[N:6]=1.[OH-].[Na+]>CO.O>[NH2:1][C:2]1[S:3][C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 20145021Ethyl 2-amino-5-(pyridin-4-yl)-1,3-thiazole-4-carboxylate

생성물 1

HCID 201449862-Amino-5-(pyridin-4-yl)-1,3-thiazole-4-carboxylic acid수율 79.8%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A mixture of ethyl 2-amino-5-(4-pyridyl)-4-thiazolecarboxylate (5.0 g) and sodium hydroxide (1.6 g) in a mixture of methanol (50 ml) and water (10 ml) was stirred at ambient temperature for an hour. The reaction mixture was evaporated in vacuo and the residue was dissolved in water. The aqueous solution was adjusted to pH 5 with 10% hydrochloric acid. The precipitate was collected by filtration and dried over phosphorus pentoxide in vacuo to afford 2-amino-5-(4-pyridyl)-4-thiazolecarboxylic acid (3.54 g).

후처리

  1. customThe reaction mixture was evaporated in vacuo
  2. dissolutionthe residue was dissolved in water
  3. filtrationThe precipitate was collected by filtration
  4. dry with materialdried over phosphorus pentoxide in vacuo

출처 및 근거

ORD 기록
ord-e48138b7789b4b7e92f7b034976d697b
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04649146

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